Does frequent treatment of frown Botox also lead to resistance?

Yes, areas like the frown lines, forehead, and around the eyes can also have a higher risk of resistance if treated repeatedly at short intervals. Frown lines are related to the contraction of the muscles around the eyebrows, and similar to the jawline, the more frequently exposed to complex proteins, the greater the possibility of neutralizing antibody formation. If you are frequently treated for fine wrinkle management, it is safer to prioritize considering highly refined pure toxin products.