Recommended Combination of RE2O and Rejuran | Summary of Synergistic Treatments That Work Well Together
2026-07-30
RE2O is a skin booster that directly injects human-derived allogeneic dermis to fill the structure within the skin.
RE2O and Rejuran have different mechanisms for filling and regeneration, so synergy can be expected when used together.
When combined with HIFU, it is recommended to wait about a week to expect synergy.
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Many people are concerned about fine lines and sagging as their skin becomes thinner and loses elasticity. In such cases, it is important to improve the structure of the skin itself by promoting collagen and elastin production. The next-generation skin booster, RE2O, has recently gained attention for this role.
In this post, we will summarize the effects of RE2O, how it differs from other collagen-promoting treatments, the treatment cycle, pain levels, and synergistic combinations.
What is RE2O Skin Booster?
RE2O is made from safe components extracted only from human skin. During this process, any cells or unnecessary parts that could cause rejection are completely removed, leaving only collagen that supports skin elasticity, elastin that provides firmness, and hyaluronic acid that maintains moisture.
Originally developed from safe components used as grafts in burn or skin reconstruction surgeries, RE2O is designed to be injected into the skin. It consists of components that can fill the structure that acts as the framework within the skin, allowing for structural improvement and long-lasting regenerative effects.
Effects and Duration of RE2O | From Immediate Filling to Long-Term Regeneration
💛Immediate Effects
Within 2 weeks after the treatment, the completed extracellular matrix components such as collagen, elastin, and hyaluronic acid quickly fill the deficient areas within the skin.
✅From Day 3 Post-Treatment: Improvement in blood circulation and skin barrier begins
✅After 1 Week: Noticeable overall changes such as pore reduction, alleviation of fine lines, and improvement in skin texture
💛Gradual Improvement Effects
As time passes, the RE2O components break down and stimulate surrounding fibroblasts, which play a role in inducing the creation of new extracellular matrix. Initially, it fills the deficient components directly, and afterward, it creates an environment where the skin can rebuild its structure on its own. Therefore, long-term regeneration can be expected rather than just temporary improvement.
Method and Pain Level of RE2O Treatment | Comparison of Hand Injection vs. Cannula
Due to the relatively larger size of the component particles, the level of pain experienced may vary depending on the injection method.
✅Needle Injection: Performed using the hand injection method, there may be a slight sting, but the pain from the medication itself is generally less than that of Rejuran.
✅Cannula Treatment: This method involves evenly injecting into the dermis using a blunt-ended cannula, resulting in less damage to the skin and surrounding areas, thus relatively lower pain levels.
Recommended Combination of RE2O and Rejuran | Synergistic Effects When Used Together
First, Rejuran is a treatment that works well when combined with RE2O. Although both treatments are categorized as 'skin boosters', their mechanisms and target groups differ. RE2O directly fills the damaged structures within the skin, namely the extracellular matrix (ECM), with collagen and elastin components, while Rejuran sends signals for cell regeneration using salmon-derived PN components, encouraging the skin to recover on its own. One fills the deficient framework from the outside, while the other helps the skin regenerate itself, making the combination of both treatments a complementary approach that can improve structure and cellular environment simultaneously.
Combining with HIFU energy treatments such as Ulthera or Shurink can also yield good results. However, it is recommended to wait about a week after HIFU treatment before proceeding. This is because RE2O is sensitive to heat, and it should be administered after the skin layer stimulated by HIFU has stabilized. Additionally, combining with Thermage or Juvelook is also considered a good synergistic combination.
If you want more detailed information about skin boosters, please click the link below.
Frequently Asked Questions
Q. How much does one session of RE2O cost?
The price of RE2O can vary depending on the treatment area and the required dosage. You can check the price of RE2O at Derna Clinic on the event page.
※Events may change or end without notice. If you cannot find the information you are looking for, please inquire for detailed guidance.
Q. Can I receive RE2O and Ulthera together?
Ulthera is a treatment that improves sagging by pulling the fascia layer (SMAS) with heat energy, while RE2O fills the density of the dermis itself, so they can be performed together as they target different layers. However, it is recommended to allow time for the skin to stabilize after heat energy stimulation, so it is advisable to proceed with a proper order and interval.
Q. Does combining RE2O with Potenza (pumping tip) yield different effects?
Improving pores and skin texture with Potenza before using the pumping tip to evenly distribute RE2O into the dermis can create a combination that addresses both pore improvement and structural regeneration. This can be considered if you are concerned about pores while also wanting to improve skin elasticity.
For more detailed information about Potenza, you can check the link below.
Q. What is the difference between RE2O and Juvelook? Can they be administered together?
Juvelook is a collagen promoter that induces self-collagen production, while RE2O directly fills with human-derived allogeneic dermis, so it is good to understand that their mechanisms differ. However, when RE2O and Juvelook are administered together, immediate filling and long-term self-regeneration can be expected, so they are often used in combination.
Q. Are there any side effects or risks of nodules with RE2O?
Temporary embossing (bumpiness), bruising, and swelling immediately after the treatment are normal reactions and often subside within a few days. Nodules (lumps) are not a common side effect, but they may occur depending on individual skin conditions or treatment methods, so it is important to receive treatment after a precise diagnosis from experienced medical professionals.
Q. How much pain does RE2O cause and what is the downtime?
Pain can be reduced by using anesthetic cream, and in the case of cannula treatment, the pain burden is relatively low. The appearance of treatment marks or swelling varies by individual, but generally subsides naturally within a few days.
Q. How often and at what intervals should RE2O be administered?
It is generally recommended to perform it at intervals of 4 weeks for at least 3 sessions, with a maintenance period of about 8 to 12 months. However, the maintenance period may vary depending on whether other treatments are performed and individual skin conditions.
Q. Who is recommended for combined RE2O treatments?
Those with thin skin and decreased elasticity, those concerned about volume loss, and those with simultaneous concerns about pores or fine lines may benefit from combined treatments for multiple layers of improvement. However, it is advisable to determine the exact combination through consultation with medical professionals.
RE2O is a skin booster that directly supplements human-derived allogeneic dermis to fill the structure within the skin, helping to improve pores, wrinkles, elasticity, and density. However, the effects may vary depending on individual skin thickness or damage, making it difficult to approach uniformly without precise diagnosis.
At Derna Clinic, we first digitize the skin condition using the EVE V MUSE 3D scanner, and then design the treatment method and combination of RE2O through 1:1 customized consultation. Since it is based on diagnostic data rather than intuition, the reliability of the results can be enhanced even for the same RE2O treatment.
We invite you to experience RE2O, accurately designed to meet the needs of your skin, at Derna Clinic, which aims for reasonable premium quality.
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